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. 1992 Jan 15;113(1):33-5.
doi: 10.1016/s0002-9394(14)75749-6.

HLA-A29.2 subtype associated with birdshot retinochoroidopathy

P LeHoang  1 , N Ozdemir, A Benhamou, T Tabary, C Edelson, H Betuel, R Semiglia, J H Cohen
Affiliations

HLA-A29.2 subtype associated with birdshot retinochoroidopathy

P LeHoang et al. Am J Ophthalmol. .

Abstract

Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P less than .01) in this study of HLA-A29 subtyping.

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