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. 2007 Jan;23(1):1-7.
doi: 10.1016/S1607-551X(09)70367-5.

Changes in gingival crevicular fluid interleukin-4 and interferon-gamma in patients with chronic periodontitis before and after periodontal initial therapy

Chi-Cheng Tsai  1 , Chia-Hsin Ku, Ya-Ping Ho, Kun-Yen Ho, Yi-Min Wu, Chun-Cheng Hung
Affiliations

Changes in gingival crevicular fluid interleukin-4 and interferon-gamma in patients with chronic periodontitis before and after periodontal initial therapy

Chi-Cheng Tsai et al. Kaohsiung J Med Sci. 2007 Jan.

Abstract

Cytokines are pivotal to the immune response of chronic periodontitis. The present study investigated the changes of gingival crevicular fluid (GCF) interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with chronic periodontitis before and after initial nonsurgical periodontal therapy (NSPT). GCF was collected from 17 patients by means of Periopaper at baseline and 1 month after NSPT. IL-4 and IFN-gamma were measured by enzyme-linked immunoabsorbent assay. NSPT resulted in decreased total amount of IFN-gamma, increased concentration of IL-4, and increased ratio of IL-4 to IFN-gamma levels. We suggest that a low ratio of IL-4 to IFN-gamma levels might be involved in the destruction (diseased sites) of periodontal tissue, whereas an increased ratio of IL-4 to IFN-gamma levels could be related to the improvement of clinical periodontal health.

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References

    1. Lindhe J, Liljenberg B, Listgarten M. Some microbiological and histopathological features of periodontal disease in man. J Periodontol. 1980; 51: 264–269. - PubMed
    1. Mackler BF, Frostad KB, Robertson PB, et al. Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease. J Periodontal Res. 1977; 12: 37–45. - PubMed
    1. Reinhardt RA, Boltton RW, McDonald TL, et al. In situ lymphocyte subpopulations from active versus stable periodontal sites. J Periodontol. 1988; 59: 656–670. - PubMed
    1. Seymour GJ, Greenspan JS. The phenotypic characterization of lymphocyte subpopulations in established human periodontal disease. J Periodontal Res. 1979; 14: 39–46. - PubMed
    1. Seymour GJ, Powell RN, Atkien JF. Experimental gingivitis in humans. A clinical and histologic investigation. J Periodontol. 1983; 54: 522–528. - PubMed

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