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. 2006 Nov;12(11):1776-8.
doi: 10.3201/eid1211.051207.

The study recurrent tuberculosis and exogenous reinfection, Shanghai, China

Guomiao Shen  1 , Zhen Xue, Xin Shen, Bin Sun, Xiaohong Gui, Mei Shen, Jian Mei, Qian Gao
Affiliations

The study recurrent tuberculosis and exogenous reinfection, Shanghai, China

Guomiao Shen et al. Emerg Infect Dis. 2006 Nov.

Abstract

Of 52 patients with recurrent tuberculosis in Shanghai, People's Republic of China, 32 (61.5%) had isolates in which genotype patterns of Mycobacterium tuberculosis differed between first and second episodes. This result indicates that exogenous reinfection is common in an area with a high incidence of tuberculosis.

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Figures

Figure 1
Figure 1
Selection of patients in the study, Shanghai, People's Republic of China, 1999–2004. TB, tuberculosis. The total number of patients from 1999 through 2004 was 6,960; among these patients, 5,688 were cured.
Figure 2
Figure 2
Genotyping analysis of clinical isolates from patients with recurrent tuberculosis. Numbers represented the patients' codes. A) Gel electrophoresis analysis of the PCR products of the mycobacterial interspersed repetitive unit (MIRU) locus 10. bp, base pair; M: DNA marker; Rv, H37Rv positive control; ck, negative control. B) IS6110 restriction fragment length polymorphism analysis of some patients with different MIRU patterns.
See this image and copyright information in PMC

References

    1. World Health Organization. Global tuberculosis control: surveillance, planning, financing. Geneva: The Organization; 2006. (WHO/HTM/TB/.362).
    1. Lambert ML, Hasker E, van Deun A, Roberfroid D, Boelaert M, van der Stuyft P. Recurrence in tuberculosis: relapse or reinfection? Lancet Infect Dis. 2003;3:282–7. 10.1016/S1473-3099(03)00607-8 - DOI - PubMed
    1. Chiang CY, Riley LW. Exogenous reinfection in tuberculosis. Lancet Infect Dis. 2005;5:629–36. 10.1016/S1473-3099(05)70240-1 - DOI - PubMed
    1. Barnes PF, Cave MD. Molecular epidemiology of tuberculosis. N Engl J Med. 2003;349:1149–56. 10.1056/NEJMra021964 - DOI - PubMed
    1. Verver S, Warren RM, Beyers N, Richardson M, van der Spuy GD, Borgdorff MW, et al. Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. Am J Respir Crit Care Med. 2005;171:1430–5. 10.1164/rccm.200409-1200OC - DOI - PubMed

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