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. 2007 Mar;70(3):332-6.
doi: 10.1021/np060308p. Epub 2007 Feb 7.

Myriaporones 1-4, cytotoxic metabolites from the Mediterranean bryozoan Myriapora truncata

Jie-Fei Cheng  1 , Jong-Soo Lee, Ryuichi Sakai, Elizabeth A Jares-Erijman, Maria V Silva, Kenneth L Rinehart
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Myriaporones 1-4, cytotoxic metabolites from the Mediterranean bryozoan Myriapora truncata

Jie-Fei Cheng et al. J Nat Prod. 2007 Mar.

Abstract

Four novel polyketide-derived metabolites, myriaporones 1, 2, 3, and 4, have been isolated from the Mediterranean bryozoan Myriapora truncata. Their structures and stereochemistry have been assigned from the analysis of spectroscopic data. The inseparable equilibrium mixture of myriaporones 3 and 4 showed 88% inhibition of L1210 murine leukemia cells at 0.2 microg/mL.

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