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Comparative Study
. 2007 Mar;17(3):293-8.
doi: 10.1101/gr.5941007. Epub 2007 Feb 6.

mtDNA phylogeny and evolution of laboratory mouse strains

Ana Goios  1 , Luísa Pereira, Molly Bogue, Vincent Macaulay, António Amorim
Affiliations
Comparative Study

mtDNA phylogeny and evolution of laboratory mouse strains

Ana Goios et al. Genome Res. 2007 Mar.

Abstract

Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

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Figures

Figure 1.
Figure 1.
Maximum likelihood phylogenetic tree of five wild-derived and three common inbred strains. Rattus norvegicus was used as an outgroup.
Figure 2.
Figure 2.
The single most parsimonious tree for complete mice mtDNA polymorphisms found in 16 different common inbred strains (19 sequences), two cell lines, and one wild-derived inbred strain (WSB).
See this image and copyright information in PMC

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