Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Feb 8:3:1.
doi: 10.1186/1745-7580-3-1.

Protein sequence database for pathogenic arenaviruses

Huynh-Hoa Bui  1 , Jason Botten, Nicolas Fusseder, Valerie Pasquetto, Bianca Mothe, Michael J Buchmeier, Alessandro Sette
Affiliations

Protein sequence database for pathogenic arenaviruses

Huynh-Hoa Bui et al. Immunome Res. .

Abstract

Background: Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machupo, Whitewater Arroyo, Lassa and LCMV).

Results: The database currently contains a non-redundant set of 333 protein sequences which were manually annotated. All entries were linked to NCBI and cited PubMed references. The database has a convenient query interface including BLAST search. Sequence variability analyses were also performed and the results are hosted in the database.

Conclusion: The database is available at http://epitope.liai.org:8080/projects/arena and can be used to aid in studies that require proteomic information from pathogenic arenaviruses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Arenavirus protein sequence database construction flowchart.
Figure 2
Figure 2
Sequence search interface.
Figure 3
Figure 3
Peptide search interface.
Figure 4
Figure 4
BLAST search interface.
Figure 5
Figure 5
Inter-virus sequence diversity of NP protein.
Figure 6
Figure 6
Inter-virus sequence diversity of GPC protein.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. McCormick JB. Epidemiology and control of Lassa fever. Curr Top Microbiol Immunol. 1987;134:69–78. - PubMed
    1. Maiztegui JI, McKee KT, Jr., Barrera Oro JG, Harrison LH, Gibbs PH, Feuillade MR, Enria DA, Briggiler AM, Levis SC, Ambrosio AM, Halsey NA, Peters CJ. Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group. J Infect Dis. 1998;177:277–283. - PubMed
    1. Maiztegui JI. Clinical and epidemiological patterns of Argentine haemorrhagic fever. Bull World Health Organ. 1975;52:567–575. - PMC - PubMed
    1. Salas R, de Manzione N, Tesh RB, Rico-Hesse R, Shope RE, Betancourt A, Godoy O, Bruzual R, Pacheco ME, Ramos B, et al. Venezuelan haemorrhagic fever. Lancet. 1991;338:1033–1036. doi: 10.1016/0140-6736(91)91899-6. - DOI - PubMed
    1. de Manzione N, Salas RA, Paredes H, Godoy O, Rojas L, Araoz F, Fulhorst CF, Ksiazek TG, Mills JN, Ellis BA, Peters CJ, Tesh RB. Venezuelan hemorrhagic fever: clinical and epidemiological studies of 165 cases. Clin Infect Dis. 1998;26:308–313. - PubMed