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. 2007 Feb 8:3:1.
doi: 10.1186/1745-7580-3-1.

Protein sequence database for pathogenic arenaviruses

Huynh-Hoa Bui  1 , Jason Botten, Nicolas Fusseder, Valerie Pasquetto, Bianca Mothe, Michael J Buchmeier, Alessandro Sette
Affiliations

Protein sequence database for pathogenic arenaviruses

Huynh-Hoa Bui et al. Immunome Res. .

Abstract

Background: Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus infections, we have developed a database containing protein sequences from the seven pathogenic arenaviruses (Junin, Guanarito, Sabia, Machupo, Whitewater Arroyo, Lassa and LCMV).

Results: The database currently contains a non-redundant set of 333 protein sequences which were manually annotated. All entries were linked to NCBI and cited PubMed references. The database has a convenient query interface including BLAST search. Sequence variability analyses were also performed and the results are hosted in the database.

Conclusion: The database is available at http://epitope.liai.org:8080/projects/arena and can be used to aid in studies that require proteomic information from pathogenic arenaviruses.

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Figures

Figure 1
Figure 1
Arenavirus protein sequence database construction flowchart.
Figure 2
Figure 2
Sequence search interface.
Figure 3
Figure 3
Peptide search interface.
Figure 4
Figure 4
BLAST search interface.
Figure 5
Figure 5
Inter-virus sequence diversity of NP protein.
Figure 6
Figure 6
Inter-virus sequence diversity of GPC protein.
See this image and copyright information in PMC

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