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. 1975 Oct;72(10):3975-7.
doi: 10.1073/pnas.72.10.3975.

Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system

M N Thang, D C Thang, E De Maeyer, L Montagnier

Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system

M N Thang et al. Proc Natl Acad Sci U S A. 1975 Oct.

Abstract

A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse cells; (2) its antiviral activity was species specific; (3) its activity was completely neutralized by mouse anti-interferon serum. The synthesis of interferon in this cell-free system requires the presence of spermine.

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