Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Oct;72(10):3975-7.
doi: 10.1073/pnas.72.10.3975.

Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system

M N Thang, D C Thang, E De Maeyer, L Montagnier

Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system

M N Thang et al. Proc Natl Acad Sci U S A. 1975 Oct.

Abstract

A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse cells; (2) its antiviral activity was species specific; (3) its activity was completely neutralized by mouse anti-interferon serum. The synthesis of interferon in this cell-free system requires the presence of spermine.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1975 Feb;72(2):701-5 - PubMed
    1. Nucleic Acids Res. 1974 Nov;1(11):1385-97 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1189-93 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 May;72(5):1922-6 - PubMed
    1. J Biol Chem. 1975 Jun 10;250(11):4139-44 - PubMed

LinkOut - more resources