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Comment
. 2007 Feb 9;128(3):433-4.
doi: 10.1016/j.cell.2007.01.017.

Visualizing the histone code on LSD1

Matthew J Gamble  1 , W Lee Kraus
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Free article
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Visualizing the histone code on LSD1

Matthew J Gamble et al. Cell. .
Free article

Abstract

In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.

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