Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2007 Feb 9;128(3):437-8.
doi: 10.1016/j.cell.2007.01.020.

Molecular events underlying pregnancy-induced cardiomyopathy

Leslie A Leinwand  1
Affiliations
Free article
Comment

Molecular events underlying pregnancy-induced cardiomyopathy

Leslie A Leinwand. Cell. .
Free article

Abstract

The etiology of cardiomyopathy in pregnant women remains unclear. In this issue, Hilfiker-Kleiner et al. (2007) report that a reduction in STAT3 and a concomitant increase in cathepsin D may be a cause of this disease. Cathepsin D generates an antiangiogenic cleavage product of the hormone prolactin. The authors show that an inhibitor of prolactin secretion may be useful in treating this disease.

PubMed Disclaimer

Comment on

  • A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.
    Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H. Hilfiker-Kleiner D, et al. Cell. 2007 Feb 9;128(3):589-600. doi: 10.1016/j.cell.2006.12.036. Cell. 2007. PMID: 17289576 Clinical Trial.

LinkOut - more resources