Review
doi: 10.1152/physiol.00034.2006.
PKA, germ cells, and fertility
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- PMID: 17289929
- DOI: 10.1152/physiol.00034.2006
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Review
PKA, germ cells, and fertility
Physiology (Bethesda).
2007 Feb.
Free article
Abstract
Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.
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