Review
doi: 10.1152/physiol.00033.2006.
Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets
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- PMID: 17289931
- DOI: 10.1152/physiol.00033.2006
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Review
Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets
Physiology (Bethesda).
2007 Feb.
Free article
Abstract
Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.
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