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Review
. 2007 Feb:22:56-64.
doi: 10.1152/physiol.00033.2006.

Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets

Abhinav Diwan  1 , Gerald W Dorn 2nd
Affiliations
Free article
Review

Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets

Abhinav Diwan et al. Physiology (Bethesda). 2007 Feb.
Free article

Abstract

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

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