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Comment
. 2007 Feb 9;315(5813):766; author reply 766.
doi: 10.1126/science.1135047.

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake"

N Chartrel  1 , R Alvear-Perez, J Leprince, X Iturrioz, A Reaux-Le Goazigo, V Audinot, P Chomarat, F Coge, O Nosjean, M Rodriguez, J P Galizzi, J A Boutin, H Vaudry, C Llorens-Cortes
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Comment

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake"

N Chartrel et al. Science. .

Abstract

Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.

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