Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2007 Feb;27(2):204-10.
doi: 10.1097/01.iae.0000248148.56560.b1.

Designing clinical trials for age-related geographic atrophy of the macula: enrollment data from the geographic atrophy natural history study

Janet S Sunness  1 , Carol A Applegate, Neil M Bressler, Barbara S Hawkins
Affiliations
Multicenter Study

Designing clinical trials for age-related geographic atrophy of the macula: enrollment data from the geographic atrophy natural history study

Janet S Sunness et al. Retina. 2007 Feb.

Abstract

Purpose: To derive information from the Geographic Atrophy (GA) Natural History Study that is relevant to recruiting patients and designing clinical trials for GA.

Methods: A prospective natural history study with annual follow-up enrolled patients with GA and no choroidal neovascularization (CNV) in at least one eye. Characteristics of recruited and enrolled patients are analyzed, in the context of progression data from the study.

Results: The data show that GA from age-related macular degeneration (AMD) was seen in 82% of the referred patients, there was an attrition rate of 14%, and 60% of the patients with GA from AMD had bilateral GA without CNV. Within the 83 patients in the bilateral GA group with follow-up, 50 patients (60%) met both the proposed visual acuity and the proposed GA area criteria for a treatment trial in one or both eyes.

Conclusion: These data should be helpful in planning future treatment trials for GA.

PubMed Disclaimer

Publication types