[Fish meat retarding the progression of chronic renal failure in spontaneously hypercholesterolemic rats]

Abstract

Objective: To investigate the effects of different dietary proteins of fish meat and casein upon the progression of chronic renal failure (CRF) in spontaneously hypercholesterolemic (SHC) rats.

Methods: 48 SHC rats of 10 weeks of age were randomly divided into four groups, and placed on diets containing 20% and 40% casein or fish protein respectively till they were 22 weeks of age. 24-hour urine collections were obtained along with measurements of systolic blood pressure and blood were drew from their tail vein evry 4 weeks. Finally, the kidneys were removed and prepared for histological and immunohistochemistry study .

Results: Fish meat diet slowed the progression of proteinuria, renal function failure and glomerular injury compared with the control casein diet in both 20% and 40% dietary groups.

Conclusion: Fish meat retarded the progression of CRF in SHC rats compared with casein.