doi: 10.1073/pnas.72.11.4464.
Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts
- PMID: 172910
- PMCID: PMC388742
- DOI: 10.1073/pnas.72.11.4464
Item in Clipboard
Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts
Proc Natl Acad Sci U S A.
1975 Nov.
Abstract
Complementary DNA (cDNA) specific for chick globin mRNA sequences fails to hybridize to total RNA extracted from chicken fibroblasts. After infection by Rous sarcoma virus, RNA complementary to globin cDNA is detectable in 100-500 copies per cell. Infection of fibroblasts with the transformation defective (td) deletion mutant of Rous sarcoma virus leads to normal virus production, but not to host cell transformation or accumulation of RNA sequences complementary to globin cDNA. Our evidence shows that the globin genes activated by Rous sarcoma virus are those specified by embryonic chick red cells; adult-specific globin sequences were not detected.
Similar articles
-
Activation of cellular genes by avian RNA tumor viruses.Proc Natl Acad Sci U S A. 1980 Sep;77(9):5351-4. doi: 10.1073/pnas.77.9.5351. Proc Natl Acad Sci U S A. 1980. PMID: 6254077 Free PMC article.
-
Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts.J Biol Chem. 1978 Aug 25;253(16):5869-74. J Biol Chem. 1978. PMID: 78927
-
Mechanism of transfection of chicken embryo fibroblasts by Rous sarcoma virus DNA.J Virol. 1978 Oct;28(1):45-52. doi: 10.1128/JVI.28.1.45-52.1978. J Virol. 1978. PMID: 212612 Free PMC article.
-
Integration of proviral DNA in chicken cells infected with Schmidt-Ruppin Rous sarcoma virus is not enhanced by DNA repair.J Virol. 1977 Sep;23(3):533-42. doi: 10.1128/JVI.23.3.533-542.1977. J Virol. 1977. PMID: 197260 Free PMC article.
-
Alteration of in vivo DNA synthesis in the alpha globin locus of chick embryo fibroblasts due to in vivo activity of Rous sarcoma virus pp60src.Nucleic Acids Res. 1994 Feb 11;22(3):498-505. Nucleic Acids Res. 1994. Corrected and republished in: Nucleic Acids Res. 1994 Apr 11;22(7):498-505. PMID: 8127691 Free PMC article. Corrected and republished.
Cited by
-
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.Proc Natl Acad Sci U S A. 1986 Dec;83(24):9413-7. doi: 10.1073/pnas.83.24.9413. Proc Natl Acad Sci U S A. 1986. PMID: 3540938 Free PMC article.
-
Developmental shifts in frequency distribution of polysomal mRNA and their posttranscriptional regulation in the sea urchin embryo.Proc Natl Acad Sci U S A. 1980 Aug;77(8):4653-6. doi: 10.1073/pnas.77.8.4653. Proc Natl Acad Sci U S A. 1980. PMID: 6933514 Free PMC article.
-
Tropomyosin is decreased in transformed cells.Proc Natl Acad Sci U S A. 1981 Sep;78(9):5633-7. doi: 10.1073/pnas.78.9.5633. Proc Natl Acad Sci U S A. 1981. PMID: 6272310 Free PMC article.
-
Avidin is induced in chicken embryo fibroblasts by viral transformation and cell damage.EMBO J. 1983;2(10):1715-9. doi: 10.1002/j.1460-2075.1983.tb01647.x. EMBO J. 1983. PMID: 6315397 Free PMC article.
-
Molecular events in cells transformed by Rous Sarcoma virus.J Cell Biol. 1980 Nov;87(2 Pt 1):319-25. doi: 10.1083/jcb.87.2.319. J Cell Biol. 1980. PMID: 6253501 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
