doi: 10.1021/np060439q.
Epub 2007 Feb 10.
Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships
Affiliations
- PMID: 17291040
- DOI: 10.1021/np060439q
Item in Clipboard
Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships
J Nat Prod.
2007 Apr.
Abstract
Four new diterpenoids, 11S-deacetylpseudolaric acid A (2), deacetylpseudolaric acid A O-beta-d-glucopyranoside (3), deacetylpseudolaric acid A 2,3-dihydroxypropyl ester (4), and deacetylpseudolaric acid B 2,3-dihydroxypropyl ester (5), and nine known diterpenoids were isolated from the bark of Pseudolarix kaempferi. Their structures were determined on the basis of chemical and spectroscopic analyses. In addition, their in vitro cytotoxic activities against three human cancer cell lines and their structure-activity relationships were evaluated.
Similar articles
-
Abietane diterpenoids from the bark of Cryptomeria fortunei.J Nat Prod. 2008 Jul;71(7):1242-6. doi: 10.1021/np8002063. Epub 2008 Jun 13. J Nat Prod. 2008. PMID: 18549276
-
Simultaneous determination of seven major diterpenoids in Pseudolarix kaempferi by high-performance liquid chromatography DAD method.J Pharm Biomed Anal. 2007 Jul 27;44(3):730-6. doi: 10.1016/j.jpba.2007.03.005. Epub 2007 Mar 14. J Pharm Biomed Anal. 2007. PMID: 17446030
-
Five new diterpenoids from Pseudolarix kaempferi.J Nat Prod. 2002 Jul;65(7):1041-4. doi: 10.1021/np0200010. J Nat Prod. 2002. PMID: 12141871
-
[Advances in study on chemical constituents and pharmacological activities of plants of genus Pteris].Zhongguo Zhong Yao Za Zhi. 2007 Jul;32(14):1382-7. Zhongguo Zhong Yao Za Zhi. 2007. PMID: 17966346 Review. Chinese.
-
Pseudolaric acids: isolation, bioactivity and synthetic studies.Nat Prod Rep. 2010 Jul;27(7):1066-83. doi: 10.1039/b906520m. Epub 2010 Apr 20. Nat Prod Rep. 2010. PMID: 20405078 Review.
Cited by
-
Total synthesis of (-)-pseudolaric acid B.J Am Chem Soc. 2008 Dec 3;130(48):16424-34. doi: 10.1021/ja806724x. J Am Chem Soc. 2008. PMID: 18998641 Free PMC article.
-
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A.Nat Prod Bioprospect. 2025 Apr 2;15(1):21. doi: 10.1007/s13659-025-00502-1. Nat Prod Bioprospect. 2025. PMID: 40172707 Free PMC article.
-
A unified approach to the daucane and sphenolobane bicyclo[5.3.0]decane core: enantioselective total syntheses of daucene, daucenal, epoxydaucenal B, and 14-para-anisoyloxydauc-4,8-diene.Chemistry. 2013 Dec 23;19(52):17745-50. doi: 10.1002/chem.201302353. Epub 2013 Dec 2. Chemistry. 2013. PMID: 24302464 Free PMC article.
-
Molecular mechanism underlying the apoptotic modulation by ethanol extract of Pseudolarix kaempferi in mucoepidermoid carcinoma of the salivary glands.Cancer Cell Int. 2021 Aug 14;21(1):427. doi: 10.1186/s12935-021-02134-0. Cancer Cell Int. 2021. PMID: 34391437 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
