Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Nov;72(11):4501-5.
doi: 10.1073/pnas.72.11.4501.

Cytochemical study of secretory process in transplantable insulinoma of syrian golden hamster

A B Novikoff, A Yam, P M Novikoff

Cytochemical study of secretory process in transplantable insulinoma of syrian golden hamster

A B Novikoff et al. Proc Natl Acad Sci U S A. 1975 Nov.

Abstract

Electron microscopy, including phosphatase cytochemistry, indicates that the secretory granules of an insulinoma producing proinsulin and insulin are packaged by the endoplasmic reticulum (ER) and especially by a specialized region of ER which we call GERL because of the spatial relationship of this region to the Golgi apparatus and its apparent role in producing lysosomes. The granules are not derived from the Golgi apparatus. Preliminary evidence suggests this may be true also of pancreatic beta-cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Endocrinology. 1975 Aug;97(2):442-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Feb;72(2):508-12 - PubMed
    1. Science. 1975 Aug 1;189(4200):347-58 - PubMed
    1. Diabetes. 1971 Jun;20(6):385-8 - PubMed
    1. J Cell Biol. 1971 Sep;50(3):859-86 - PubMed

Publication types

MeSH terms

LinkOut - more resources