[Acute and late toxicities in thoracic irradiation]

Abstract

Radiotherapy of lung cancer is often complexe because of several organs at risk such as lung, heart, esophagus or spinal cord. An accurate balance needs to be defined between the necessities to reach a local control and to limit the risks of toxicities for each of them. Several parameters were significantly correlated with radiation induced lung toxicities (V13, V20, 30, Mean Dose) and esophagitis (V40 to V60). However no parameters are clearly defined for heart toxicities. The large number of parameters described for lung and esophagus highlights the necessity to perform an overall analysis of the DVHs that could be possible by using Nomal Tissue Complication Probability models.