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. 1992 Jan;174(2):619-22.
doi: 10.1128/jb.174.2.619-622.1992.

Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo

I Iost  1 , J Guillerez, M Dreyfus
Affiliations

Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo

I Iost et al. J Bacteriol. 1992 Jan.

Abstract

We show that in Escherichia coli at 32 degrees C, the T7 RNA polymerase travels over the lacZ gene about eightfold faster than ribosomes travel over the corresponding mRNA. We discuss how the T7 phage might exploit this high rate in its growth optimization strategy and how it obviates the possible drawbacks of uncoupling transcription from translation.

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References

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