A radical role for p38 MAPK in tumor initiation
- PMID: 17292820
- DOI: 10.1016/j.ccr.2007.01.009
A radical role for p38 MAPK in tumor initiation
Abstract
It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress.
Comment on
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p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.Cancer Cell. 2007 Feb;11(2):191-205. doi: 10.1016/j.ccr.2006.12.013. Cancer Cell. 2007. PMID: 17292829
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