Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jul;21(4):173-82.
doi: 10.1016/j.blre.2006.12.001. Epub 2007 Feb 12.

Farnesyltransferase inihibitors in hematologic malignancies

Jean-Luc Harousseau  1
Affiliations
Review

Farnesyltransferase inihibitors in hematologic malignancies

Jean-Luc Harousseau. Blood Rev. 2007 Jul.

Abstract

Farnesyltransferase inhibitors (FTIs) inhibit certain cellular signal transduction pathways, and are being evaluated for activity in hematologic malignancies. Tipifarnib and lonafarnib are orally available FTIs that are active against a variety of targets and inhibit several pathways involved in the pathogenesis of hematologic malignancies. FTIs have demonstrated activity in a variety of hematologic diseases, including acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia, and multiple myeloma. This article reviews the clinical experience with tipifarnib and lonafarnib in the treatment of hematologic malignancies.

PubMed Disclaimer

MeSH terms

LinkOut - more resources