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. 2006 Dec;101(8):845-9.
doi: 10.1590/s0074-02762006000800004.

Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil

Luzidalva Barbosa de Medeiros  1 , Heloísa Ramos Lacerda, Ana Maria Salustiano Cavalcanti, Maria de Fátima Pessoa Militão de Albuquerque
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Free article

Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil

Luzidalva Barbosa de Medeiros et al. Mem Inst Oswaldo Cruz. 2006 Dec.
Free article

Abstract

To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeq Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.

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