Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan 1;89(1):232-5.
doi: 10.1073/pnas.89.1.232.

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice

S Suematsu  1 , T Matsusaka, T Matsuda, S Ohno, J Miyazaki, K Yamamura, T Hirano, T Kishimoto
Affiliations

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice

S Suematsu et al. Proc Natl Acad Sci U S A. .

Abstract

The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.

PubMed Disclaimer

References

    1. EMBO J. 1990 Mar;9(3):897-905 - PubMed
    1. Cell. 1990 Jun 15;61(6):1121-35 - PubMed
    1. J Exp Med. 1984 Jun 1;159(6):1762-77 - PubMed
    1. Nature. 1984 Jan 26-Feb 1;307(5949):334-40 - PubMed
    1. Immunol Today. 1990 Dec;11(12):443-9 - PubMed

Publication types

LinkOut - more resources