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. 2007 Feb 13;176(4):441-2.
doi: 10.1503/cmaj.061689.

Copy-number variations add a new layer of complexity in the human genome

Robert A Hegele  1
Affiliations

Copy-number variations add a new layer of complexity in the human genome

Robert A Hegele. CMAJ. .
No abstract available

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Figure. Variations were previously thought to occur mainly at the level of single base pairs of DNA. However, numerous submicroscopic chromosomal changes involving more than 1000 to half a million or more base pairs have recently been identified. These copy-number variations or CNVs could explain differences in disease susceptibility among individuals and eventually lead to improved prevention and treatment approaches for particular diseases. Photo by: iStockphoto
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