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. 2007 Feb 15;79(4):1661-7.
doi: 10.1021/ac061824n.

"Click" modification of silica surfaces and glass microfluidic channels

Shaurya Prakash  1 , Timothy M Long, John C Selby, Jeffrey S Moore, Mark A Shannon
Affiliations

"Click" modification of silica surfaces and glass microfluidic channels

Shaurya Prakash et al. Anal Chem. .

Abstract

This paper demonstrates a chemical surface modification method for covalent attachment of various polymers by using silane-based "click" chemistry on silica surfaces and within glass microchannels suitable for CE systems. Modified surfaces are characterized by contact angle measurements, X-ray photoelectron spectroscopy, and Fourier transform infrared-attenuated total reflection spectroscopy. Electroosmotic flow (EOF) measurements in modified and unmodified channels are provided. Spectroscopic and transport data show that various polymers can be covalently attached to glass surfaces with a measurable change in EOF.

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