doi: 10.1016/0090-6980(75)90135-5.
ACTH-induced prostaglandin biosynthesis from 3H-arachidonic acid by adrenocortical cells
- PMID: 172981
- DOI: 10.1016/0090-6980(75)90135-5
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ACTH-induced prostaglandin biosynthesis from 3H-arachidonic acid by adrenocortical cells
Prostaglandins.
1975 Sep.
Abstract
Prostaglandins biosynthesized from 3H-arachidonic acid by trypsin-dispersed cat adrenocortical cells were isolated by silicic acid and thin layer chromatography. PGE, PGF, and a third component with mobility properties indistinguishable from either PGA or PGB were identified both in cortical cell homogenates and incubation medium. Concentrations of ACTH (125-250 muU) which stimulate steroidogenesis enhanced the conversion of labeled precursor to all three of these prostaglandins. These findings provide further evidence for the proposal that prostaglandins function as a critical link in ACTH-induced steroidogenesis.
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