Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan;50(1):76-83.

Aphidicolin-inducible common fragile-site expression: results from a population survey of twins

M J Austin  1 , J M Collins, L A Corey, W E Nance, M C Neale, R M Schieken, J A Brown
Affiliations

Aphidicolin-inducible common fragile-site expression: results from a population survey of twins

M J Austin et al. Am J Hum Genet. 1992 Jan.

Abstract

Common chromosomal fragile sites appear to be ubiquitous in humans and other mammals, and, although the molecular basis and function of these sites remain an enigma, it has been speculated that they may be a cytogenetic expression of gene activity. A population survey of 28 twin pairs was conducted to assess the heritability of common fragile-site expression. Our data yielded a heritability estimate of .88 for total site expression, suggesting that these sites may result from some common process that is under relatively stringent genetic control. An analysis of the expression of individual autosomal sites revealed that expression on both homologues in the same cell occurred more frequently than expected.

PubMed Disclaimer

References

    1. Oncogene. 1987 Mar;1(1):59-69 - PubMed
    1. Hum Genet. 1988 Dec;81(1):9-12 - PubMed
    1. Cytogenet Cell Genet. 1987;46(1-4):316-24 - PubMed
    1. Chromosoma. 1987;96(1):45-9 - PubMed
    1. Jinrui Idengaku Zasshi. 1988 Sep;33(3):355-64 - PubMed

LinkOut - more resources