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Clinical Trial
. 2007 Jul;78(7):760-3.
doi: 10.1136/jnnp.2006.088450. Epub 2007 Feb 13.

Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: results of a pilot study

María del Mar Matarín  1 , Roser Pueyo, María Antonia Poca, Carles Falcón, María Mataró, Núria Bargalló, Juan Sahuquillo, Carme Junqué
Affiliations
Clinical Trial

Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: results of a pilot study

María del Mar Matarín et al. J Neurol Neurosurg Psychiatry. 2007 Jul.

Abstract

Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.

Objectives: We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation.

Methods: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values.

Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.

Conclusion: MRS could be a marker of neuronal dysfunction in NPH.

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Conflict of interest statement

Competing interests: None.

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