Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jul;91(7):905-7.
doi: 10.1136/bjo.2006.111252. Epub 2007 Feb 14.

Retinal nerve fibre thickness measured with optical coherence tomography accurately detects confirmed glaucomatous damage

D C Hood  1 , N Harizman, F N Kanadani, T M Grippo, S Baharestani, V C Greenstein, J M Liebmann, R Ritch
Affiliations

Retinal nerve fibre thickness measured with optical coherence tomography accurately detects confirmed glaucomatous damage

D C Hood et al. Br J Ophthalmol. 2007 Jul.

Abstract

Aim: To assess the accuracy of optical coherence tomography (OCT) in detecting damage to a hemifield, patients with hemifield defects confirmed on both static automated perimetry (SAP) and multifocal visual evoked potentials (mfVEP) were studied.

Methods: Eyes of 40 patients with concomitant SAP and mfVEP glaucomatous loss and 25 controls underwent OCT retinal nerve fibre layer (RNFL), mfVEP and 24-2 SAP tests. For the mfVEP and 24-2 SAP, a hemifield was defined as abnormal based upon cluster criteria. On OCT, a hemifield was considered abnormal if one of the five clock hour sectors (3 and 9 o'clock excluded) was at <1% (red) or two were at <5% (yellow).

Results: Seventy seven (43%) of the hemifields were abnormal on both mfVEP and SAP tests. The OCT was abnormal for 73 (95%) of these. Only 1 (1%) of the 100 hemifields of the controls was abnormal on OCT. Sensitivity/specificity (one eye per person) was 95/98%.

Conclusions: The OCT RNFL test accurately detects abnormal hemifields confirmed on both subjective and objective functional tests. Identifying abnormal hemifields with a criterion of 1 red (1%) or 2 yellow (5%) clock hours may prove useful in clinical practice.

PubMed Disclaimer

Comment in

References

    1. Kerrigan‐Baumrind L A, Quigley H A, Pease M E.et al Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci 200041741–748. - PubMed
    1. Zangwill L M, Williams J, Berry C C.et al A comparison of optical coherence tomography and retinal nerve fiber layer photography for detection of nerve fiber layer damage in glaucoma. Ophthalmol 20001071309–1315. - PubMed
    1. Sanchez‐Galeana C, Bowd C, Blumenthal E Z.et al Using optical imaging summary data to detect glaucoma. Ophthalmology 20011081812–1818. - PubMed
    1. Nouri‐Mahdavi K, Hoffman D, Tannenbaum D P.et al Identifying early glaucoma with optical coherence tomography. Am J Ophthalmol 2004137228–235. - PubMed
    1. Budenz D L, Michael A, Chang R T.et al Sensitivity and specificity of the StratusOCT for perimetric glaucoma. Ophthalmology 20051123–9. - PubMed

Publication types