doi: 10.1126/science.173020.
Tumorigenicity of mouse-human diploid hybrids in nude mice
- PMID: 173020
- DOI: 10.1126/science.173020
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Tumorigenicity of mouse-human diploid hybrids in nude mice
Science.
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Abstract
Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.
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