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Review
. 2007 Mar;147(3):401-11.
doi: 10.1111/j.1365-2249.2006.03306.x.

Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis

C Sander  1 , H McShane
Affiliations
Review

Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis

C Sander et al. Clin Exp Immunol. 2007 Mar.

Abstract

Tuberculosis (TB) continues to be a major global health disaster, despite the widespread use of BCG and effective drug therapies. The development of an efficacious new TB vaccine would be an important component of disease control in the future. Many approaches are being utilised to enhance understanding of the requirements of a successful vaccine. Numerous vaccines are being designed and assessed in a series of animal models, with a few progressing to clinical trials. Here, the steps involved in the development and evaluation of TB vaccines will be discussed, including description of the most frequently used animal models and the processes involved in advancing vaccines to phase III trials.

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References

    1. Kochi A. The global tuberculosis situation and the new control strategy of the World Health Organization. Tubercle. 1991;72:1–6. - PubMed
    1. Russell S. The economic burden of illness for households in developing countries: a review of studies focusing on malaria, tuberculosis, and human immunodeficiency virus/acquired immunodeficiency syndrome. Am J Trop Med Hyg. 2004;71(Suppl 2):147–55. - PubMed
    1. Dye C, Watt CJ, Bleed DM, Hosseini SM, Raviglione MC. Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally. JAMA. 2005;293:2767–75. - PubMed
    1. Grant AD, Djomand G, De Cock KM. Natural history and spectrum of disease in adults with HIV/AIDS in Africa. Aids. 1997;11(Suppl B):S43–54. - PubMed
    1. [2 January 2007]. http://www.who.int/tb/dots/en/