Review
doi: 10.1016/j.coi.2007.02.011.
Epub 2007 Feb 15.
T-cell potential and development in vitro: the OP9-DL1 approach
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- PMID: 17303399
- DOI: 10.1016/j.coi.2007.02.011
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Review
T-cell potential and development in vitro: the OP9-DL1 approach
Curr Opin Immunol.
2007 Apr.
Abstract
In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.
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