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Review
. 2007 Apr;19(2):163-8.
doi: 10.1016/j.coi.2007.02.011. Epub 2007 Feb 15.

T-cell potential and development in vitro: the OP9-DL1 approach

Renée de Pooter  1 , Juan Carlos Zúñiga-Pflücker
Affiliations
Review

T-cell potential and development in vitro: the OP9-DL1 approach

Renée de Pooter et al. Curr Opin Immunol. 2007 Apr.

Abstract

In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.

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