Comment
doi: 10.1124/mol.107.035196.
Epub 2007 Feb 15.
The thrill can kill: murder by methylation
Affiliations
- PMID: 17303699
- DOI: 10.1124/mol.107.035196
Item in Clipboard
Comment
The thrill can kill: murder by methylation
Mol Pharmacol.
2007 May.
Abstract
Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. (p. 1319) show that a specific methylation occurs at the protein kinase Cepsilon (PKCepsilon) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKCepsilon, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.
Comment on
-
Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart.Mol Pharmacol. 2007 May;71(5):1319-28. doi: 10.1124/mol.106.032011. Epub 2007 Jan 3. Mol Pharmacol. 2007. PMID: 17202284
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
