doi: 10.1016/0039-128x(75)90081-1.
Estrogen receptor in rat liver and its dependence on prolactin
- PMID: 173045
- DOI: 10.1016/0039-128x(75)90081-1
Item in Clipboard
Estrogen receptor in rat liver and its dependence on prolactin
Steroids.
1975 Sep.
Abstract
Estrogen receptor is shown to be present in the livers of adult rats. The receptor binds estradiol-17beta with a Kd of 1 x 10(-10) M and sediments at 8 S in sucrose gradients. Other estrogens and anti-estrogens compete for estradiol binding, while nonestrogenic steroids do not. Receptor levels fall dramatically after hypophysectomy, but can be partially restored within 18 hours by a single injection of prolactin. It is known that prolactin critically regulates the level of its own receptor in the liver, and we now suggest that it also exerts a primary control over the availability of liver estrogen receptor.
Similar articles
-
Induction of a lactogenic receptor in rat liver: influence of estrogen and the pituitary.Proc Natl Acad Sci U S A. 1974 Jun;71(6):2407-10. doi: 10.1073/pnas.71.6.2407. Proc Natl Acad Sci U S A. 1974. PMID: 4366766 Free PMC article.
-
Effects of hypophysectomy, ovariectomy, and cycloheximide on specific binding sites for lactogenic hormones in rat liver.Endocrinology. 1975 Dec;97(6):1408-15. doi: 10.1210/endo-97-6-1408. Endocrinology. 1975. PMID: 173523
-
Regulation of estrogen receptors in ovarian-dependent rat mammary tumors. I. Effects of castration and prolactin.Endocrinology. 1976 Mar;98(3):722-9. doi: 10.1210/endo-98-3-722. Endocrinology. 1976. PMID: 177271
-
Hormone dependence in breast cancer.Metabolism. 1974 Jan;23(1):75-100. doi: 10.1016/0026-0495(74)90106-1. Metabolism. 1974. PMID: 4357247 Review. No abstract available.
-
A new approach for selecting patients with metastatic breast cancer for hypophysectomy.Clin Neurosurg. 1974;21:39-59. doi: 10.1093/neurosurgery/21.cn_suppl_1.39. Clin Neurosurg. 1974. PMID: 4371771 Review. No abstract available.
Cited by
-
Determination and properties of proteohormone receptors in malignant gynecological tumors with special reference to lactogen receptors in human breast cancer.Arch Gynecol. 1980;229(4):333-44. doi: 10.1007/BF02108584. Arch Gynecol. 1980. PMID: 6251754
-
Partial purification and characterization of oestrogen receptors in subfractions of hepatocyte plasma membranes.Biochem J. 1980 Dec 1;191(3):743-60. doi: 10.1042/bj1910743. Biochem J. 1980. PMID: 7283971 Free PMC article.
-
Regenerating rat liver: correlations between estrogen receptor localization and deoxyribonucleic acid synthesis.Gastroenterology. 1984 Mar;86(3):552-7. Gastroenterology. 1984. PMID: 6693017 Free PMC article.
-
High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens.Exp Eye Res. 2013 Jul;112:1-9. doi: 10.1016/j.exer.2013.04.002. Epub 2013 Apr 15. Exp Eye Res. 2013. PMID: 23597597 Free PMC article.
-
Tamoxifen prevents induction of hepatic neoplasia by zeranol, an estrogenic food contaminant.Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1085-9. doi: 10.1073/pnas.89.3.1085. Proc Natl Acad Sci U S A. 1992. PMID: 1736291 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
