Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Feb;60(2):602-5.
doi: 10.1128/iai.60.2.602-605.1992.

Genetic association of mating types and virulence in Cryptococcus neoformans

K J Kwon-Chung  1 , J C Edman, B L Wickes
Affiliations

Genetic association of mating types and virulence in Cryptococcus neoformans

K J Kwon-Chung et al. Infect Immun. 1992 Feb.

Abstract

A pair of congenic Cryptococcus neoformans var. neoformans strains, B-4476 (a mating type) and B-4500 (alpha mating type), that presumably differ only in mating type was constructed. This pair and their progeny, five alpha type and five a type, were tested for virulence in mice. In the parent strains as well as the progeny, alpha type was clearly more virulent than a type. In addition, death tended to occur earlier among the alpha-strain-infected mice that died than among the mice that died by infection caused by a strains. These data strongly suggest the genetic association of virulence with mating type in this human fungal pathogen.

PubMed Disclaimer

References

    1. Mol Cell Biol. 1990 Sep;10(9):4538-44 - PubMed
    1. Exp Parasitol. 1989 Apr;68(3):274-82 - PubMed
    1. Sabouraudia. 1984;22(2):155-7 - PubMed
    1. J Bacteriol. 1982 Jun;150(3):1414-21 - PubMed
    1. Antonie Van Leeuwenhoek. 1982;48(1):25-38 - PubMed

Publication types

LinkOut - more resources