doi: 10.1176/ajp.134.6.665.
Benzodiazepines: behavioral and neurochemical mechanisms
- PMID: 17305
- DOI: 10.1176/ajp.134.6.665
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Benzodiazepines: behavioral and neurochemical mechanisms
Am J Psychiatry.
1977 Jun.
Abstract
The therapeutic effects of benzodiazepines in psychoneurosis may depend in part on their ability to release or disinhibit a patient's anxiety-suppressed gratification-seeking behavior. Benzodiazepines may disinhibit behavior by reducing the activity of serotonin (and possibly acetylcholine) neurons in the brain's "punishment" system. Reduction of serotonin transmission may be due to a facilitation of gamma-aminobutyric acid (GABA)-mediated presynaptic inhibition at the serotonin nerve terminal.
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