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. 2007 Mar 16;72(6):2046-52.
doi: 10.1021/jo062365t. Epub 2007 Feb 17.

Asymmetric synthesis of ring functionalized trans-2,6-disubstituted piperidines from N-sulfinyl delta-amino beta-keto phosphonates. total synthesis of (-)-myrtine

Franklin A Davis  1 , He Xu, Junyi Zhang
Affiliations

Asymmetric synthesis of ring functionalized trans-2,6-disubstituted piperidines from N-sulfinyl delta-amino beta-keto phosphonates. total synthesis of (-)-myrtine

Franklin A Davis et al. J Org Chem. .

Abstract

Sulfinimine-derived N-sulfinyl delta-amino beta-ketophosphonates are transformed via the enaminones to the phosphoryl dihydropyridones that selectively give trans-2,6-disubstituted 1,2,5,6-tetrahydropyridines on organocuprate addition and dephosphorylation.

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