Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Mar;36(3):173-6.
doi: 10.1111/j.1600-0714.2007.00520.x.

LOH at chromosome 9q34.3 and the Notch1 gene methylation are less involved in oral squamous cell carcinomas

Shan Gao  1 , Annelise Krogdahl, Hans Eiberg, Chung-Ji Liu, Jens Ahm Sørensen
Affiliations

LOH at chromosome 9q34.3 and the Notch1 gene methylation are less involved in oral squamous cell carcinomas

Shan Gao et al. J Oral Pathol Med. 2007 Mar.

Abstract

Background: Previous studies of oral carcinomas have shown that both loss of heterozygosity (LOH) and hypermethylation at chromosome 9q33 to 9q34.2 are frequent. The present study investigates the frequency of Notch1 gene methylation and LOH at 9q34.3 region.

Methods: Gene promoter hypermethylation of the Notch1 gene was analysed by methylation-specific PCR and LOH was analysed using microsatellite markers.

Results: We found LOH at 9q34.3 in three patients and methylation of the Notch1 gene only in two patients with oral carcinoma.

Conclusion: Comparing with the alterations at 9q33 to 34.2 regions, LOH at 9q34.3 and methylation of the Notch1 gene was less involved in oral squamous cell carcinomas.

PubMed Disclaimer

Substances

LinkOut - more resources