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Case Reports
. 2007 Feb 16:5:19.
doi: 10.1186/1477-7819-5-19.

Multiple rectal carcinoids with diffuse ganglioneuromatosis

Masashi Haraguchi  1 , Hideki Kinoshita, Miho Koori, Noritsugu Tsuneoka, Taiichiro Kosaka, Yuji Ito, Junichiro Furui, Takashi Kanematsu
Affiliations
Case Reports

Multiple rectal carcinoids with diffuse ganglioneuromatosis

Masashi Haraguchi et al. World J Surg Oncol. .

Abstract

Background: Rectal carcinoids comprise only about 1% of all anorectal neoplasms. In addition, ganglioneuroma of the gastrointestinal tract is a rare tumor composed ganglion cells, nerve fibers, and supporting cells. Multiple carcinoid tumors with diffuse ganglioneuromatosis limited to the rectum are quite unusual.

Case presentation: A 69-year-old man was referred to us because of about 100 small submucosal rectal tumors. He underwent abdominoperineal resection. Pathology revealed carcinoid tumors for about 30 submucosal nodules and diffuse ganglioneuromotosis. To date (6 months later) he remains well with no recurrence.

Conclusion: Although the optimal treatment for the multiple rectal carcinoids remains to be clearly established, it is believed that not all patients with multiple rectal carcinoids (measuring less than 1 cm in diameter) need to have a radical operation. However, the treatment plan for each case should be individualized and a careful follow-up is mandatory.

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Figures

Figure 1
Figure 1
a) Macroscopic findings of the resected rectum demonstrating multiple submucosal tumors. 1.b) A schematic drawing of the resected rectum showing the location of submucasal tumors (●).1.c) A schematic drawing of the resected rectum showing the location of carcinoid tumors (formula image).
Figure 2
Figure 2
a) A carcinoid tumor proliferating submucosa b) A carcinoid tumor: uniform small round, polygonal prominent round nuclei.
Figure 3
Figure 3
a) A section of the mucosa and submucosa showing extensive ganglioneuromatosis b) A ganglion cell (arrow) is surrounded by spindle cells.
See this image and copyright information in PMC

References

    1. Winburn GB. Multiple rectal carcinoids: a case report. Am Surg. 1998;64:1200–1203. - PubMed
    1. Sumida T, Nagata S, Ougoshi H, Ishida Y, Kuwahara T, Tatsugami M, Tsuji K, Hidaka T, Tachiyama Y, Kaneko M, Hayashi Y. Multiple rectal carcinoid tumors treated by endoscopic mucosal resection-Report of a case. Gastroenterol Endosc. 2005;47:1419–1424. (in Japanease)
    1. Rafiq S, Hameer H, Sitrin MD. Ganglioneuromatous polyposis associated with juvenile polyps and a tubular adenoma. Dig Dis Sci. 2005;50:506–508. doi: 10.1007/s10620-005-2465-4. - DOI - PubMed
    1. Kanter AS, Hyman NH, Li SC. Ganglioneuromatous polyposis: a premalignant condition. Report of a case and review of the literature. Dis Colon Rectum. 2001;44:591–593. doi: 10.1007/BF02234335. - DOI - PubMed
    1. Jetmore AB, Ray JE, Gathright JB, Jr, McMullen KM, Hicks TC, Timmcke AE. Rectal carcinoids: the most frequent carcinoid tumor. Dis Colon Rectum. 1992;35:717–725. doi: 10.1007/BF02050318. - DOI - PubMed

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