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Review
. 2007 Mar;150(3):216-9.
doi: 10.1016/j.jpeds.2006.12.048.

Patent ductus arteriosus: evidence for and against treatment

Ronald I Clyman, Nancy Chorne
Review

Patent ductus arteriosus: evidence for and against treatment

Ronald I Clyman et al. J Pediatr. 2007 Mar.
No abstract available

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Figures

Figure
Figure
Relationship between treatment times in randomized PDA trials and the occurrence of common neonatal morbidities. Each trial type (Prophylactic or Symptomatic) entered infants into an Initial Early treatment or Control (no treatment) group. Several days later a Back up treatment was used to close any remaining clinically significant PDA shunts. These trials can detect morbidities affected by the PDA that present or develop during the interval between Initial and Back up treatments (i.e., during the interval that the ductus is closed in the Early group and open in the Control group). For example, Prophylactic trials have the potential to examine the role of PDA on the incidence of ICH or pulmonary hemorrhage, whereas the symptomatic trials would not be able to examine this relationship. Conversely, the Symptomatic trials might be able to examine the relationship between PDA and NEC, whereas the Prophylactic trials would be unlikely to do so. Shaded bar represents the postnatal age when a morbidity either develops or is apparent. Shaded bars with ??? represent morbidities that may or may not have their origins during this period.
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Comment in

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References

    1. Loftin CD, Trivedi DB, Tiano HF, Clark JA, Lee CA, Epstein JA, et al. Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. Proc Natl Acad Sci U S A. 2001;98(3):1059–64. - PMC - PubMed
    1. Campbell M. Natural history of persistent ductus arteriosus. Br Heart J. 1968;30:4–13. - PMC - PubMed
    1. Brooks JM, Travadi JN, Patole SK, Doherty DA, Simmer K. Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management. Arch Dis Child Fetal Neonatal Ed. 2005;90:F235–9. - PMC - PubMed
    1. Van Israel N, Dukes-McEwan J, French AT. Long-term follow-up of dogs with patent ductus arteriosus. J Small Anim Pract. 2003;44(11):480–90. - PubMed
    1. Heymann MA, Rudolph AM, Silverman NH. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med. 1976;295(10):530–3. - PubMed

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