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. 2007 May;51(5):1882-4.
doi: 10.1128/AAC.01525-06. Epub 2007 Feb 16.

Candida albicans and Candida dubliniensis respond differently to echinocandin antifungal agents in vitro

Mette D Jacobsen  1 , Julie A Whyte, Frank C Odds
Affiliations

Candida albicans and Candida dubliniensis respond differently to echinocandin antifungal agents in vitro

Mette D Jacobsen et al. Antimicrob Agents Chemother. 2007 May.

Abstract

Candida dubliniensis isolates tested for susceptibility to anidulafungin, caspofungin, and micafungin commonly showed artifactual regrowth and/or trailing effects with MIC tests done under conditions involving a high initial yeast concentration. The artifacts were less common with Candida albicans and seldom seen for either species under Clinical and Laboratory Standards Institute method M27-A test conditions.

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Figures

FIG. 1.
FIG. 1.
Examples of dose-response curves for isolates tested showing normal echinocandin susceptibility and a typically sigmoid dose response (open squares) for caspofungin versus C. dubliniensis 75/043; reduced susceptibility and a typical dose-response curve (open circles) for caspofungin versus C. albicans T26; a trailing growth effect (open triangles) for anidulafungin versus C. dubliniensis B71507; a paradoxical regrowth effect (closed circles) for caspofungin versus C. dubliniensis 910Aa); and a trailing growth plus paradoxical effect (closed squares) for micafungin versus C. dubliniensis J931021.
See this image and copyright information in PMC

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