Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Nov-Dec;72(6):845-8.
doi: 10.1016/s1808-8694(15)31054-5.

Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi's anemia

Henrique de Lins e Horta  1 , Fernando Fernandes Guimarães, Luiz Otávio Savassi Rocha, Roberto Eustáquio Santos Guimarães, Eugênia Ribeiro Valadares
Affiliations
Review

Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi's anemia

Henrique de Lins e Horta et al. Braz J Otorhinolaryngol. 2006 Nov-Dec.

Abstract

Fanconi's anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors. Due to inherent characteristics to this syndrome, the treatment of such neoplasms is particularly difficult. In this paper we report the case of a 24-year-old woman with Fanconi's anemia who developed a squamous cell carcinoma of the hypopharynx; she had none of the traditional risk factors, such as smoking and alcohol abuse. We also briefly review the literature about this topic.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Tumor view at videolaryngoscopy: vegetating lesion involving mostly the left piriform cavity.
Figure 2
Figure 2
Neck CT scan, axial view: tumor mass in the left piriform cavity.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fanconi G. Familiäre infantile perniziösaartige Anämie (perniziöses Blutbild und Konstitution) Jahrb Kinderheilkund. 1927;117:257–280.
    1. Alter BP, Young NS. In: Hematology of infancy and childhood. Nathan DG, Orkin SH, editors. Saunders; Philadelphia, PA: 1998. The bone marrow failure syndromes; pp. 237–335.
    1. Venkitaraman AR. A growing network of cancer-susceptibility genes. N Engl J Med. 2003;348(19):1917–1919. - PubMed
    1. Rosenberg PS, Greene MH, Alter BP. Cancer incidence in persons with Fanconi anemia. Blood. 2003;101:822–826. - PubMed
    1. Kutler DI, Singh B, Satagopan J, Batish SD, Berwick M, Giampietro PF, et al. A 20-year perspective on the International Fanconi Anemia Registry (IFAR) Blood. 2003;101:1249–1256. - PubMed

Uncited Reference

    1. Alter BP. Cancer in Fanconi anemia, 1927-2001. Cancer. 2003;97:425–440. - PubMed