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Review
. 2007 Mar;21(3):303-10.
doi: 10.1111/j.1468-3083.2006.02008.x.

Psoriasis vulgaris and human leukocyte antigens

F F Cassia  1 , S C Carneiro, M T Q Marques, L F Pontes, A L Filgueira, L C S Porto
Affiliations
Review

Psoriasis vulgaris and human leukocyte antigens

F F Cassia et al. J Eur Acad Dermatol Venereol. 2007 Mar.

Abstract

Background: Psoriasis vulgaris is a skin disease with a complex immunological and genetic background, triggered by environmental factors. The association of human leukocyte antigens (HLA) and psoriasis has long been reported on population and familial studies.

Objectives: To review and discuss studies on psoriasis vulgaris and HLA, in Caucasian and non-Caucasian populations.

Methods: The major population studies on psoriasis vulgaris and the associated HLA antigens and alleles are described and discussed based on a review of the current literature.

Results: Population studies demonstrate the presence of different HLA specificities as well as extended haplotypes in patients with psoriasis, when compared to controls. Some alleles occur in a lower frequency in patients with psoriasis, indicating they could be protection alleles. In all studies which HLA class I was typed, Cw6 or Cw*0602 was present in a significant frequency in patients with psoriasis, mainly when early onset and positive family history were considered. HLA-DRB1*0701 was also present in a higher frequency in patients in different populations.

Conclusions: Different antigens and alleles from both HLA classes I and II were seen in a significantly higher frequency in patients with psoriasis vulgaris. HLA Cw*0602 and DRB1*0701 were represented in different reports, and the former was related mainly to psoriasis type I.

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