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. 2007 Apr;114(4):493-7.
doi: 10.1111/j.1471-0528.2007.01238.x. Epub 2007 Feb 19.

Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice

B Weisz  1 , P Pandya, L Chitty, P Jones, W Huttly, C Rodeck
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Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice

B Weisz et al. BJOG. 2007 Apr.

Abstract

We have evaluated a cohort of women booked for antenatal care at University College London Hospitals. The uptake of screening was 64.4% and was significantly higher (73 versus 46%) in women who booked before 14 weeks. Of the women who booked before 14 weeks, 96.8% opted for the integrated test (IT). Overall, 5.3% failed to attend for the second blood test. The false-positive rate in the women who had the IT was 2.9%. All 11 cases of Down syndrome were detected prenatally. Our study is the first to evaluate implementation of the IT into routine clinical practice.

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