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Comparative Study
. 2007 Feb 20;68(8):603-5.
doi: 10.1212/01.wnl.0000254502.87233.9a.

A secondary progressive clinical course is uncommon in neuromyelitis optica

D M Wingerchuk  1 , S J Pittock, C F Lucchinetti, V A Lennon, B G Weinshenker
Affiliations
Comparative Study

A secondary progressive clinical course is uncommon in neuromyelitis optica

D M Wingerchuk et al. Neurology. .

Abstract

We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.

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