Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Aug;24(1):53-7.
doi: 10.1007/s11239-007-0011-2. Epub 2007 Feb 20.

Effect of taurine on endotoxin-induced alterations in plasma asymmetric dimethylarginine, L-arginine and nitric oxide in guinea pigs

Affiliations

Effect of taurine on endotoxin-induced alterations in plasma asymmetric dimethylarginine, L-arginine and nitric oxide in guinea pigs

Barbaros Balabanli et al. J Thromb Thrombolysis. 2007 Aug.

Abstract

The effect of taurine on the plasma levels of L-arginine, asymmetrical dimethylarginine (ADMA) and L-arginine/ADMA ratio and nitric oxide was investigated in experimental endotoxemia. L-arginine and ADMA levels were quantified by high performance liquid chromatography with fluorescence detector. Nitric oxide level was measured with spectrophotometric method. All experiments were performed with four groups (control, taurine, endotoxemia, taurine plus endotoxin) of 10 guinea pigs. After the endotoxin was administrated (4 mg/kg) ADMA level increased, nitric oxide level did not change but L-arginine level and L-arginine/ADMA ratio decreased. When taurine was administrated (300 mg/kg) no effect on ADMA and nitric oxide levels was observed compared to the endotoxemia group. But it was increased the L-arginine/ADMA ratio. Taurine may offer an advantage in because of it increases the reduced L-arginine/ADMA ratio.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Atheroscler Suppl. 2003 Dec;4(4):33-40 - PubMed
    1. J Surg Res. 2000 May 1;90(1):51-7 - PubMed
    1. Circulation. 2003 Dec 16;108(24):3042-7 - PubMed
    1. Adv Exp Med Biol. 1998;442:169-76 - PubMed
    1. J Chromatogr B Biomed Sci Appl. 1997 May 9;692(2):467-71 - PubMed

Publication types

LinkOut - more resources