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Controlled Clinical Trial
. 2007 Mar;137(3 Suppl 2):791S-3S.
doi: 10.1093/jn/137.3.791S.

Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity

Kazuyoshi Takeda  1 , Ko Okumura
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Free article
Controlled Clinical Trial

Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity

Kazuyoshi Takeda et al. J Nutr. 2007 Mar.
Free article

Erratum in

Abstract

Nine healthy middle-aged and 10 elderly volunteers drank fermented milk containing 4 x 10(10) live cells of Lactobacillus casei strain Shirota daily for 3 wk, and their natural killer (NK) activity and other immunological functions were examined. In the experiments with middle-aged volunteers, NK activity significantly increased (P<0.01) 3 wk after the start of intake, elevated NK cell activity remained for the next 3 wk, and this effect was particularly prominent in the low-NK-activity individuals. In the experiments with elderly volunteers, NK activity significantly decreased (P<0.01) in the control group 3 wk after the start of intake; however, the intake of Lactobacillus casei strain Shirota maintained the NK activity. These results suggest that daily intake of Lactobacillus casei strain Shirota provides a positive effect on NK-cell activity.

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