Comment on

• Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study.

  Leyland-Jones B, Semiglazov V, Pawlicki M, Pienkowski T, Tjulandin S, Manikhas G, Makhson A, Roth A, Dodwell D, Baselga J, Biakhov M, Valuckas K, Voznyi E, Liu X, Vercammen E. Leyland-Jones B, et al. J Clin Oncol. 2005 Sep 1;23(25):5960-72. doi: 10.1200/JCO.2005.06.150. Epub 2005 Aug 8. J Clin Oncol. 2005. PMID: 16087945 Clinical Trial.
• Erythropoietin use in cancer patients: a matter of life and death?

  Steensma DP, Loprinzi CL. Steensma DP, et al. J Clin Oncol. 2005 Sep 1;23(25):5865-8. doi: 10.1200/JCO.2005.05.036. Epub 2005 Aug 8. J Clin Oncol. 2005. PMID: 16087951 No abstract available.
• Epoetin alfa and darbepoetin alfa go head to head.

  Steensma DP, Loprinzi CL. Steensma DP, et al. J Clin Oncol. 2006 May 20;24(15):2233-6. doi: 10.1200/JCO.2006.05.7794. J Clin Oncol. 2006. PMID: 16710021 No abstract available.
• Randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia: the 20030125 Study Group Trial.

  20030125 Study Group Trial; Glaspy J, Vadhan-Raj S, Patel R, Bosserman L, Hu E, Lloyd RE, Boccia RV, Tomita D, Rossi G. 20030125 Study Group Trial, et al. J Clin Oncol. 2006 May 20;24(15):2290-7. doi: 10.1200/JCO.2005.03.8570. J Clin Oncol. 2006. PMID: 16710026 Clinical Trial.
• Understanding the presence and function of erythropoietin receptors on cancer cells.

  Lai SY, Grandis JR. Lai SY, et al. J Clin Oncol. 2006 Oct 10;24(29):4675-6. doi: 10.1200/JCO.2006.08.1190. J Clin Oncol. 2006. PMID: 17028292 No abstract available.
• Do erythropoietin receptors on cancer cells explain unexpected clinical findings?

  Henke M, Mattern D, Pepe M, Bézay C, Weissenberger C, Werner M, Pajonk F. Henke M, et al. J Clin Oncol. 2006 Oct 10;24(29):4708-13. doi: 10.1200/JCO.2006.06.2737. J Clin Oncol. 2006. PMID: 17028293
• Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia.

  Wright JR, Ung YC, Julian JA, Pritchard KI, Whelan TJ, Smith C, Szechtman B, Roa W, Mulroy L, Rudinskas L, Gagnon B, Okawara GS, Levine MN. Wright JR, et al. J Clin Oncol. 2007 Mar 20;25(9):1027-32. doi: 10.1200/JCO.2006.07.1514. Epub 2007 Feb 20. J Clin Oncol. 2007. PMID: 17312332 Clinical Trial.